Basic & Translational Diabetes Research

Translational Diabetes research is a bidirectional process that involves multidisciplinary integration among basic, clinical, practice, population, and policy-based research. The goal of translational research is to speed up scientific discovery into patient and community benefit. This Research provides an overview of key concepts, methods, and trial types in translational diabetes research. The primary focus is on dissemination and implementation (D&I) research, or the systematic study of processes and factors that lead to widespread use and successful integration of evidence-based interventions into real-world clinical and community settings.

Clinical Diabetes

The mission of Clinical Diabetes is to provide primary care providers and all clinicians involved in the care of people with diabetes with information on advances and state-of-the-art care for people with diabetes. Clinical Diabetes is also a forum for discussing diabetes-related problems in practice, medical-legal issues, case studies, digests of recent research, and patient education materials.

Diabetes Therapeutics

Diabetes Technology & Therapeutics is used of new devices, drug delivery systems, and software for managing diabetes. The field of diabetes management is rapidly evolving because of the introduction of recently engineered devices and drugs. This Diabetes Technology & Therapeutics emerging applications of bioengineering tools for diabetes management, including the use of optics, material science, controlled drug release, tissue engineering, informatics, modeling, genomics, imagery, and microelectronic mechanical systems (MEMS). Diabetes Technology & Therapeutics fosters the development and use of new and emerging technologies to be applied to diabetes.

Nutrition—Clinical

Clinical Nutrition provides essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support.

Diabetes - Acute and Chronic Complications

The acute and chronic complications of diabetes account for the morbidity and mortality associated with this disease. Acute complications include diabetic ketoacidosis, hyperosmolar hyperglycemic nonketotic coma, and hypoglycemia. Chronic hyperglycemia is central to the pathophysiology of chronic complications such as cardiovascular and peripheral vascular disease, retinopathy, nephropathy, and neuropathy. Pathophysiology and assessment of, and interventions for these complications are discussed.

Diabetes and Metabolism

Diabetes & Metabolism is a scientific works of considerable significance and impact in all fields of Diabetes research such as: Type 1 Diabetes, Type 2 Diabetes, Gestational Diabetes, Monogenic Diabetes, and cystic fibrosis-related diabetes, Latent autoimmune diabetes of adults (LADA), Diabetic Neuropathy, Diabetic Retinopathy, Diabetic Nephropathy, Diabetic hypoglycemia, and Obesity.

Integrated Physiology/Obesity

The Integrative Physiology research group focuses on mechanisms underlying metabolic disorders with particular, but not exclusive, focus on insulin resistance in skeletal muscle.

Using novel methodology developed in the group to incubate and analyse human skeletal muscle samples ex-vivo, we were the first to demonstrate defects in insulin stimulation of intracellular signalling molecules in patients with insulin resistant type 2 diabetes mellitus.

The effects of exercise and muscle contraction in regulation of insulin sensitivity both whole body and in muscle is also a key area of investigation, as are effects of skeletal muscle immobility and/or denervation.

Clinical investigations in, parallel with primary human skeletal muscle cultures, where skeletal muscle cells are grown in vitro from patient biopsies, and model organisms are used to approach metabolic disease from a multidisciplinary angle in order to address gene and protein regulation, cell physiology and whole body metabolism.

Diabetes - Epidemiology & Management

Diabetes Management presents findings, analysis and commentary on the battle with Type I and Type II diabetes. Articles published in Diabetes Management address improvements in current therapeutics and patient compliance together with perspectives on future prospects. Coverage focuses on the key objective of stabilizing blood glucose levels in individuals with either form of the disease, and the associated issues of patient cooperation and education. The journal also reflects the frontiers of current research, such as attempts to recreate pancreatic cells through stem cell technology or islet cell transplantation, the development of a vaccine for Type 1 disease and the potential for biomarkers to be used for the detection. The increasing understanding of the molecular basis of the disease and associated genetics will play an important part in future diabetes management.

Gestational Diabetes and Pregnancy

Gestational diabetes is first analysed amid pregnancy. Like type 1 and type 2 diabetes, gestational diabetes causes glucose levels to wind up noticeably too high. When you eat, your stomach related framework separates the greater part of the sustenance into a sugar called glucose. It's the purpose at which the blood sugar level (glucose level) of the mother goes too high amid pregnancy. Gestational diabetes creates when your body can't deliver enough of the hormone insulin amid pregnancy. Insulin is very important to move aldohexose what your body utilizes for vitality into the cells. Without enough insulin, you can develop excessively glucose in your blood, prompting a higher-than-typical blood glucose level and maybe gestational diabetes. The higher blood glucose level in gestational diabetes caused by hormones discharged by the placenta amid pregnancy. The placenta delivers a hormone called the human placental lactogen (HPL), otherwise called human chorionic somatomammotropic (HCS). According to the International Diabetes Federation in 2016, it absolutely was estimated that 420 million adult populations is laid low with diabetes that is increasing at the speed of 8.4% and is expected to reach 625 million by 2040. According to the American Pregnancy Association, approximately 2-5% of pregnant women develop gestational diabetes; this number may increase to 7-9% of mothers who are more likely to have risk factors.

Insulin Signaling, Action & Secretion

The maintenance of normal carbohydrate metabolism requires an intricate interplay between insulin action and insulin secretion. Type 2 diabetes usually results from a combination of peripheral insulin resistance and defects in β-cell function. Analysis in humans has identified specific genetic defects associated with early-onset forms of diabetes, but a common molecular mechanism for the majority of cases of type 2 diabetes has yet to be identified. Recent results from a number of murine knockout and transgenic models suggest that disruption of insulin/insulin-like growth factor (IGF)-1 signaling mechanisms, and in particular, alteration in the function of insulin-receptor substrate (IRS) proteins, might contribute to defects in both peripheral insulin action and β-cell function. These studies identify a potential common final pathway to explain the cellular and physiological defects observed in type 2 diabetes. While the exact molecular nature of such defects in humans has yet to be identified, components of the insulin/IGF signaling network and its downstream effector molecules are attractive therapeutic targets for the rationale treatment of this disease.

Genetics and Diabetes

The diabetes of the young patients is more in now a day this session states that it is happening through the genes of our parents. The bulk of genetic risk of polygenic disease (for Type 1 and Type 2) stay unresolved. The unresolved problem of this polygenic disease are various identification methods on a raising factors.  This subject of the genetics of diabetes deals with the further information of the genetic basis of diabetes and its complications, specifically Diabetic Nephrosis (DN), recent advances in genetic science of diabetes, Diabetes in ethnic teams, genetic manner interactions and understanding the genetic science of diabetes. The diabetes is under United Nations agency and area unit in danger and targeted treatment/interventional methods. Diabetic amyotrophic is discussing that disabling sickness that's distinct from alternative types of diabetic neuropathy. Diabetic neuropathy is the deficiency of the damages on the nerves and diseases on nerves.

Diabetes Technology

Diabetes technology is the term used to describe the hardware, devices, and software that people with diabetes use to help manage blood glucose levels, stave off diabetes complications, reduce the burden of living with diabetes, and improve quality of life. Historically, diabetes technology has been divided into two main categories: insulin administered by syringe, pen, or pump, and blood glucose monitoring as assessed by meter or continuous glucose monitor. More recently, diabetes technology has expanded to include hybrid devices that both monitor glucose and deliver insulin, some automatically, as well as software that serves as a medical device, providing diabetes self-management support. Diabetes technology, when applied appropriately, can improve the lives and health of people with diabetes; however, the complexity and rapid change of the diabetes technology landscape can also be a barrier to patient and provider implementation.

Metabolic Syndrome and Related Disorders

The metabolic syndrome in the diabetes and its complications plays a role of the detailed structure of risk factors in it. The metabolic syndrome is a  the most dangerous heart attack risk factors which is a huge cluster of it, diabetes, pre diabetes, abdominal obesity, high cholesterol and high blood pressure. People with Type 1 diabetes does not affect the metabolic syndrome heavily. But in another case the view is   People with metabolic syndrome have a five-fold greater risk of developing Type 2 diabetes.  The 200 million people which is up to 80% with diabetes globally will die of cardiovascular disease.  The way ahead of HIV/AIDS in morbidity and mortality terms puts the metabolic syndrome and diabetes. The morbidity and mortality terms tell that the serious danger actions of diabetes

Behavioural Medicine & Psychology

Behavioural medicine is the interdisciplinary field concerned with the development and integration of behavioural, psychosocial, and biomedical science knowledge and techniques relevant to the understanding of health and illness, and the application of this knowledge and these techniques to prevention, diagnosis, treatment and rehabilitation. Consumers and a wide variety of health professionals are involved in behavioural medicine research and practice, including cardiologists, counselors, epidemiologists, exercise physiologists, family physicians, health educators, internists, nurses, nutritionists, pediatricians, psychiatrists and psychologists. Behavioural medicine takes a lifespan approach to health and health care, working with children, teens, adults and seniors individually and in groups, and working with racially and ethnically diverse communities.

Endocrinology, Diabetes & Metabolism Case Reports

This session discusses about the case reports in a variety of disciplines in diabetes including endocrinology, metabolic bone disease and osteoporosis, thyroid disease, pituitary and lipid disorders. The aim of the Endocrinology, Diabetes & Metabolism Case Reports and case series is to share knowledge and experience in the field of endocrine system and its associated diseases.

Novel Biomarkers for Diabetes

The prevalence of diabetes is spiralling globally with an estimated 425 million adults having diabetes in 2017 and 629 million by 2045. In the year 2017 alone, diabetes caused an estimated 4 million deaths and a global economic health related expenditure of ~730 billion US$. In recent few years a number of promising blood and urine-based biomarkers of inflammatory, endothelial, and microbiome origin, for diabetic complications have been identified. However, identifying biomarkers for diabetes and its complications remains challenging due to the heterogeneous nature.

Exercise Physiology and Therapy

Diabetes & Cardiovascular Disease