Day 1 :
Keynote Forum
Premanidhi Panda
Dr. Panda Diabetes Institute, India
Keynote: Very low calorie diet can reverse Type 2 Diabetes
Time : 09:00 AM
Biography:
Premanidhi Panda completed his MBBS from Berhampur University, India and Post-doctoral studies, MD (MED) from Utkal University School of Medicine. He is the Director of Dr. Panda Diabetes Institute, India, a premier Diabetes Hospital and Research Centre in India. He worked in Tisco Hospital (India), Benghazi Medical (Libya), and Medwin Hospital. He was awarded with India’s Best Doctor Award-2013 (diabetes) by Medgate Today Survey. He was awarded MRCP, FRCP by Royal College of Physician and Surgeon. He published more than 20 papers in reputed journals and received several national and international awards for his contribution in Diabetes.
Abstract:
Very low calorie diets generally contain about 800 calories per day, or even less.Usally Plan for Obesity. But Author apply to Type 2 Diabetes from 2015-17 Obese & Non-Obese variety.Out of 500 Patient in his study He gave Only one-two Roti Or One cup of Rice,one to two Egg White Or 2Pieces of Fish Or 6Pieces of Chicken Plus Dal,Buta,Chana Or Rajma Plus Green Vegetables Plus Palak Plus 5-10 Petals of Garlic Plus One Onion per day,2Cucumber per Day,Two Tomato per day Plus one Lemon per day.In the Breakfast limited to 1-2Oats Idli mixed with Arugula is an extremely healthy and nutritious cruciferous vegetable that many people have never heard of. Also called salad rocket or garden rocket, it has a distinctive and delicious peppery flavor to its soft green leaves and goes particularly well in fresh salads like this.Or 1/2Cup of Upama Vegetable Or Biri and Suji Pitha,Kalara Piza(Chakuli) along with one Avocado per week,Or 1/2Hybrid Guava Or 8Almonds per day Plus 4Cups of Coffee per day controls Diabetes Very Perfectly.Dr Panda Never Advised for Artificial Sweetener. Author has never found any Side effects of the diet include fatigue, mild nausea, constipation, or diarrhoea and dizziness.
Discussion:-Dr Panda only advised for one Chapati per Meal 1 chapati has only 80 to 110 calories depending on size, but it has 3.5 grams of protein, half a gram of total fat, no saturated or trans fat, no cholesterol, but it has vitamin A, B1, B2, B3, calcium, iron and fiber. Egg white is the name for the clear liquid contained within an egg contains only 17calorie. Cholesterol 0 mg.One fish Rohu contains in 100gms 97 calories in a 1 piece serving of Rohu Fish. Calorie breakdown: 12% fat, 0% carbs, 88% protein. 110 calories in 100 grams of Skinless Chicken Breast.
There are 65 calories in 100 grams of Mixed Vegetables (Without Salt, Frozen, Drained, Cooked, Boiled).
There are 160 calories in 100 grams of Avocados.
Guava also helps in regulating metabolism which leads to weight loss contains There are 68 calories in 100 grams of Guava. Calorie breakdown: 11% fat, 75% carbs, 13% protein.
10 Almonds Contains 70 Calorie.
One ounce(30ml) of scotch whiskey contains about 64-80 calories.I used to advice 2Ounce per week of alcohol is allowed.
VLCD lowers glucose production by: 1) decreasing the conversion of lactate and amino acids into glucose; 2) decreasing the rate of liver glycogen conversion to glucose; and 3) decreasing fat content, which in turn improves the liver's response to insulin. These positive effects of the VLCD were observed in just three days.
"Using this approach to comprehensively interrogate liver carbohydrate and fat metabolism, we showed that it is a combination of three mechanisms that is responsible for the rapid reversal of hyperglycaemia following a very low calorie diet, “said Dr Panda.Dr Panda found only with little Dose of Oral Hypoglycimic drug can achieve very good control Blood glucose.
Dr Panda has used Glimiperide, Metformin, Pioglitazone in combination. In some patient he has used Voglibose, Metformin and Glimiperide in combination. In many of the patient he has stopped use of Insulin along with VLCD.
Conclusion:- Patient with very low calorie diet can reverse Type 2 Diabetes or with maintain with little OHD very well due to Reduce Fat in the diet can reduce fat in Pancreas thus through diet can re-start the normal production of insulin, reversing Type 2 diabetes. This reversal with little OHD or without Medicine can help the patient Diabetes, obesity , high blood pressure and heart attack free life.
THUS I HAVE TOLD “TYPE II DIABETES IS BLESSING IN DISGUISE”
Keynote Forum
Joseph F. Ndisang
University of Saskatchewan College of Medicine,Canada
Keynote: Heme oxygenase is a molecular switch that can be upregulated against diabetic nephropathy
Time : 10.00
Biography:
Dr. Joseph Fomusi Ndisang is an Associate Professor in the University of Saskatchewan College of Medicine, Department of Physiology. He received postdoctoral training in Physiology at the University of Saskatchewan College of Medicine from 2000-2005. He obtained a PhD in Pharmacology & Toxicology from the University of Florence, Italy, 2000. He obtained a Doctor of Pharmacy degree from University of Florence, Italy in 1995. He has received several distinguished awards and distinctions including: (i) Fellow of the Canadian Cardiovascular Society (FCCS) in 2016, (ii) Fellow of the American Heart Association (FAHA) in 2011; (iii) Fellow of the International College of Angiology (FICA) in 2007; (iv) Young Investigator Award by International College of Angiology (2007); (v) Young Investigator Award by the American Society of Pharmacology & Experimental Therapeutics-Division for Drug Discovery, Development & Regulatory Affairs (2005); (vi) Young Investigator Award by the Society of Experimental Biology and Medicine (2005); (vii) Caroline tum Suden/Frances A Hellebrandt Professional Opportunity Award for Meritorious Research by the American Physiological Society (2005); and (viii) Recognition Award for Meritorious Research by a Young Investigator by the American Physiological Society (2004).
Abstract:
- Diabetes and its Treatment
Diabetes Complications
Diabetic Eye Disease (Diabetic Retinopathy)
Diabetic Kidney Disease (Diabetic Nephropathy)
Clinical Diabetes and Diagnostic Approaches
Diabetes Management
Advanced Technologies & Treatments for Diabetes
Genetics of Diabetes
Diabetes Oral Medications/Anti-Diabetic Medications
Emerging Focus in Diabetes Research
Session Introduction
Khalid Khalaf Alharbi
King Saud University, Saudi Arabia
Title: Association between Paraoxonase-1 gene polymorphism studies in the Saudi population with type 2 diabetes mellitus
Biography:
Abstract:
Diabetes has become one of the epidemic diseases producing serious physical damage and economic burden in the global population. However, Type 2 Diabetes Mellitus (T2DM) is a major kind of diabetes defined as non-insulin dependent diabetes mellitus which is more prevalent in occurring the chronic diseases and recognized as one of the multifactorial disease. Several prospectives and case-control studies have confirmed the Q192R polymorphisms in Paraoxonase-1 (PON1) gene as disease causing variant in multiple diseases in the global wide. The earlier studies from Saudi Arabia with Q192R polymorphism has confirmed as the positive associations and the present study aims to investigate the possible association between Q192R polymorphism and T2DM in the Saudi population. In this study, we have selected 400 T2DM cases and 400 healthy controls from the Saudi subjects. Serum sample was used for the biochemical analysis and peripheral blood collected in the EDTA tube was used for molecular analysis to carry out the extraction of genomic DNA. Genotyping was performed in all the 800 samples with rs662 (Q192R) polymorphism with polymerase chain reaction-restriction fragment length polymorphism method followed by 2.5% of agarose gel. The clinical characteristics were significantly higher in T2DM cases compared with controls, and also with both allele and genotype frequencies [R vs. Q: odds ratio (OR), 1.659; 95% confidence interval (95% CI), 1.344-2.048; P = 0.0002; RR vs. QQ; OR, 2.1; 95% CI, 1.3-3.2; P = 0.001; QR+RR vs. QQ; OR, 2.101; 95% CI, 1.583-2.788; P = 0.0002)]. Multiple regression analysis showed positive correlation of lipid profile with genotype (P < 0.05). The present findings provide robust evidence of PON1 Q192R polymorphism being associated with T2DM in a Saudi population.
Goutam Kumar Acherjya
Upazila Health Complex, Bangladesh.
Title: Central Nervous System Manifestations In Diabetes Mellitus
Biography:
I am basically an Internist. Now he is working as a Consultant of Medicine in the Southern part of Bangladesh. I am consulting more than fifty patients daily including OPD and inpatients for the last seven years. I have completed MBBS from Sher-E-Bangladesh Medical College Hospital, Barisal, Bangladesh in 2003. I have achieved my Fellowship (FCPS) in Internal Medicine from Bangladesh College of Physicians and Surgeons in 2011. As a researcher he has nine publications and two interesting case reports. His area of interest in research is the effects of Diabetes on degenerative Central Nervous System Diseases and Gerontology.
Abstract:
Diabetes mellitus is considered one of the main threats to human health in the 21st century. By 2030, the global estimate is expected to rise over 552 million - 9.9 % of the adult population. Diabetic Neuropathy is estimated to affect nearly 50% of patients with diabetes mellitus and is associated with significant increase in morbidity and mortality. A wide variety of disturbances affecting the central and peripheral nervous systems, either directly or indirectly, may be encountered in patients with diabetes mellitus. Neuropathies are common in both type 1 and type 2 diabetes and there are no major structural differences in the pathology of the nerves in the two diabetes types. Peripheral neuropathy has been the primary neuroscience focus of diabetes research. Contrary to some early impressions, however, the CNS is not spared by diabetes. The impact of diabetes mellitus on the CNS has gained attention only recently. Chronically, diabetes mellitus affects the CNS in several ways. Diabetes increases stroke risk and damage, overtreatment with insulin or oral agents can permanently damage the brain, and diabetes may increase the prevalence of seizure disorders. Diabetes changes brain barrier transport, blood flow and metabolism, and may produce a chronic encephalopathy. Acutely, glycemic extremes cause coma, seizures, focal neurological deficits, and impaired consciousness. The pathophysiological basis for these marked CNS abnormalities seen in hypoglycemia, hyperosmolar coma, and ketoacidosis are largely unknown.
M. S. Umashankar
SRM University, India
Title: A study of effect of cephalosporin Drug loaded topical nanogel formulation on the bacterial
Biography:
M. S. Umashankar has his expertise in novel formulation development and evaluation. He is having more than 12 years of experience in formulation development including mucoadhesive drug delivery systems for various diseases along with teaching and administration positions. Two of his renowned work on Biopolymeric Pharmaceutical Applications have patented under Intellectual Property India. Recent research publications towards patient’s health care management and well-being make new pavements to realize new ideas and novelistic approach in drug delivery design and developments.
Abstract:
Diabetic foot ulcers (DFUs) are a frequent complication of diabetes with a heavy bacterial load that lead to severe and persistent infections leading to amputation of extremities thereby affecting the quality of life of diabetes patients. Therapeutics currently on usage involves wound dressings which deliver drugs to alleviate pain and foul odors found ineffective until today. The necessity to develop and improve the efficacy of wound healing suitable for DFU treatment has been a challenge for both researchers and clinicians. An ideal formulation of topical nanotechnology-based drug delivery formulation is expected to bring new hope for diabetic foot ulcer treatment. The present investigation is to develop nanogel loaded with second generation cephalosporin for topical applications for the treatment of diabetic foot ulcer, to examine its significance against bacterial load of the DFU by sustained drug release conferring prolonged time of action to improve wound healing. An Innovative aspect of formulating a calcium phosphate nanocarrier system core called as aquasome capable to get coating on its surface a mono or bi lamella of sugars like trehalose or cellobiose forms a sugar coated nanocore which is capable of adsorbing the cephalosporin drug, a phenomenal drug carrying technique. This is formulated into suitable topical antibacterial nanogel. The antibacterial activity of drug-loaded aqua nanogel was tested on bacterial load of diabetic foot ulcer infection against gram-negative and gram-positive organisms using agar well diffusion. The zone of inhibition revealed total eradication of pathogens. The results in this research have confirmed that aqua nanogel can be a potential carrier system for cephalosporins drug to target gram-negative, gram-positive multi drug resistant microorganisms for the treatment of diabetic foot ulcers. The prepared NPs have been perceived to be stable as carrying positive zeta of more than +50 mV and were displaying homogeneity in both size and shape.
Saneh Khunkaew
1University of Wollongong School of Nursing, Australia
Title: Quality of Life and Self-care Management of Foot Care Behavior among Thai People with Diabetes Type 2
Biography:
Saneh Khunkaew is a lecturer at Boromarajonani College of Nursing Uttaradit, Thailand. He has completed his master degree from Malardaren University, Sweden. At the moment, he is doing a doctoral degree at the University of Wollongong, School of Nursing, NSW, Australia. He is an expert on diabetic foot care. His passion is to develop the quality of life and patient outcome among people with diabetes type 2 and its complications. Also he is interested in the mixed methods design in nursing research.
Abstract:
Diabetes mellitus type 2 is a chronic disease which causes high blood glucose levels. It impacts on quality of life by limiting a person’s energy to carry out physical and other activities. Despite this impact, the quality of life among people with diabetes mellitus type 2 has not been studied extensively in specific ethnic groups. This study aimed to describe the quality of life and self-care management behavior relating to foot care among Thai adults with and without diabetic foot ulcers (DFUs). A total of 502 participants with and without DFUs completed the survey in 2016. There was a statistically significant difference between people with DFUs and without DFUs (P < 0.05) on all six subscales of the Diabetes-39 survey. The overall QOL and overall severity for patients with DFUs and without DFUs was 61.18 ± 18.74, and 28.45 ± 20.56 respectively. Furthermore, 51.2% of the surveyed population lacked knowledge on basic foot care, including how to use a mirror to check the undersides of their feet. In addition, 48.8% of participants did not have a mirror for this purpose. DFU’s are a significant complication of diabetes mellitus type 2, and it is important that all people with diabetes have the knowledge they require to prevent this complication. This study contributes to knowledge about foot care practices and assists the healthcare professional to develop an educational program for people with diabetes mellitus type 2. This study also contributes to knowledge about diabetes complications and how healthcare professionals can promote a better quality of life for people with diabetes.
Milton Enrique Londoño Lemos
Manuela Beltrán University. Colombia.
Title: Leptin acts as a biomarker that predisposes children and adolescents to adult obesity and metabolic syndrome
Biography:
Milton Londoño-Lemos has her expertise in neuro-pharmacology of obesity. He is currently a professor and researcher at the Vice-rectory of Research of the Physiotherapy Program at UNIVERSIDAD MANUELA BELTRÁN. Recently. His main lines of research are Neuro-Psico-Appetite Pharmacology, Coordination Chemistry, and Biochemical Medicinal Chemistry, field where he develops two postdoctoral stays. He recently published an article called "synthesis, chemical characterization and antiadipogenic anti-obesity activity of coordination compounds derived from a serotoninergic ligand and transition metals" a book called "Obesity: Pharmacology, Neuroscience and Public Policies", which was launched at XXX international book fair of Bogota by Editorial Kinesis at 2017. He is actually working on a research project called: REGULATION OF LEPTINA IN THE SCHOOL POPULATION EXPOSED OF DEVELOPING INFANT OBESITY IN COLOMBIA-DISTRICT SCHOOLS OF BOGOTÁ.
Abstract:
Leptin is an adipokine secreted by adipose tissue and regulates both food intake and energy balance in normal weight subjects. Its discovery has been received with great expectation as a potential anti-obesity therapy, due to its ability to reverse excess adiposity in animal models characterized by a hormone deficiency; Leptin dramatically reduces body fat, suppresses appetitive behaviors and improves other endocrine-sensitive and metabolic leptin abnormalities in children and adults with congenital hormone deficiency.
On the other hand, in 2007, the International Diabetes Federation (IDF) proposed the latest definition of MS for children over the age of 10 years, based on the presence of increased waist circumference plus two of the following elements: hypertriglyceridemia; low HDL cholesterol; hypertension; and impaired fasting glucose or T2DM.
Therefore, in this work leptin is presented as a potential biomarker that predisposes children and adolescents to adult obesity, since it is usual for obese individuals to have higher levels of circulating leptin and more adipose tissue, consequently developing resistance to the effects of satiety of the hormone or hyperleptinemia. Likewise Leptin's role as a biomarker for metabolic syndrome has been researched in different populations. Regardless of which demographic studied, elevated leptin levels are associated with metabolic syndrome.
There are multiple factors, which include high levels of endogenous leptin or the intake of certain dietary components, such as fructose and saturated fats. What you should do is make people more sensitive to the hormone. To do this, a diet based on foods rich in leptin should be implemented to allow it to pass through the blood and later into the hypothalamus to function as a signal that induces an inhibition of appetite or employing physical activity that is an adjuvant for hormonal functionalization and regulation of body weight.
Biography:
Abstract:
We found significant relations of serum hepcidin with estradiol, progestron, CT assessed abdominal fat subcutaneous fat (SCF),peritoneal visceral fat(PVF) and liver density, IR indices{fasting blood sugar (FBS), fasting insulin and HOMA-IR} and metabolic syndrome (MetS) among 64postmenpausal (groupI) and 96fertile women (groupII).Among groupII, hormonal assay and hepcidin (ELISA Sandwich method) were assessed during early follicular(groupIIF )and mid luteal phases (groupIIL). GroupI compared to groupIIF and groupIIL, showed significant higher hepcidin (12.8±3.8 versus 6.5±2.6 & 9.5±3.7(ng/ml),p <0.001),iron, ferritin, hepcidin/ferritin ratio(HFR), IR indices. Also theses parameters including hepcidin were significant higher among group IIL than grouIIF . Among these three groups, hepcidin had significant positive correlations with ferritin , IR indices ,BMI, waist hip ratio(WHR), blood pressure, lipid profile,SCF, PVF and liver density , and significant negative correlation with iron, HDL and eGFR. Interestingly, hepcidin showed significant positive correlations with estradiol (p<0.001, p=0.013) and progesterone (p<0.001,p=0.003) among groupI& groupIIF. . Hepcidin levels increased significantly and linearly with increasing number of MetS features. Among groupIIF and group I, cut off points of hepcidin for prediction of MetS were >5.8 and >10.3 ng/ml with AUC of 0.91, sensitivity 93.3 % & 100% ; specificity 71.4%& 76.5 % respectively. Stepwise regression analysis for hepcidin as dependent factor: independent factors were: BMI, ferritin, HFR , cholesterol, creatinine among groupI &groupII; insulin and HOMA-IR among groupI & groupIIF; iron , LDL , DBP , WHR among groupII,; SCF among groupI; liver density, PVF& Hb among groupIIL; and SBP, FBS, progesteron , eGFR , TG and HDL-C among groupIlF.
Muhammad Asif Rasheed
COMSATS Institute of Information Technology, Sahiwal, Pakistan
Title: Inhibition of 2C Coxsackie B virus protein to decrease pathogenicity of diabetes mellitus Type1
Biography:
Abstract:
Type 1 diabetes mellitus is one of the most common disease in different area of world now a days. Enterovirus infections have been implicated in the development of the disease. The viral protein 2C Coxsackie is thought to be responsible for destruction of beta cells in pancreas. The blocking of 2C Coxsackie can be a milestone to decrease pathogenicity of the disease. By using different bioinformatics tools and databases, there is a need to design an inhibitor against virulence protein of diabetes.