Day 1 :
- Diabetes Management | Diabetes Complications: Human Organs | Diabetes and Vascular Disease | Metabolic Responses and Nutrition
Session Introduction
Omar Ziad Ameer
Alfaisal University, Saudi Arabia
Title: Regional aortic vascular dysfunction in a rodent model of metabolic syndrome
Biography:
Omar Z Ameer is a physio-pharmacologist who graduated with a PhD in Advanced Medicine from Macquarie University at the Australian School of Advanced Medicine in 2015. Thereafter, Dr Ameer pursued his post-doctoral training within the area of neuroscience and surgery at the Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, Ohio. Dr Ameer published a book and over 50 peer-reviewed publications, scored 682 citations (Google Scholar) and accumulated 96.96 global impact points (Research Gate). He currently holds the position of Head of the Pharmaceutical Sciences Department at the College of Pharmacy, Alfaisal University, KSA.
Abstract:
Obesity and diabetes constitute a hallmark of metabolic syndrome that is directly linked to vascular dysfunction. Accordingly, we aimed to investigate regional changes in thoracic and abdominal aortic responses in a rat model of high fat diet (HFD) and streptozotocin (STZ)-induced diabetes mellitus. Five weeks old male Wistar albino rats (n=24) were fed with either HFD (45 kcal% fat) or control diet (10 kcal% fat) for 10 weeks. On week 7, 40mg/kg STZ and saline were injected intraperitoneally into the HFD and control groups, respectively. At the end of the treatment, the oral glucose tolerance test (oGTT) was performed and rats were subsequently euthanized to assess vasoconstrictor and vasodilator responses of dissected aortic segments. oGTT generated greater AUCs in HFD relative to control rats (64,361±383 vs. 14,169±398, p<0.001). Abdominal aortic vasoconstriction (N/g) to norepinephrine (NE, 1×10-9–3×10-5M) and the depolarizing signals of high K+ (KCl, 5–120 mM) were higher (p<0.05) in the HFD group relative to controls. Thoracic aortic vasoconstrictor responses (N/g) to NE, but not high K+, were greater (p<0.05) in the HFD group compared with controls. Thoracic and abdominal endothelium-dependent vasorelaxation to acetylcholine (1×10-10–1×10-5M) was blunted (p<0.05) in the HFD group relative to controls. In contrast, thoracic and abdominal aortic responses to sodium nitroprusside (SNP)-induced endothelium-independent relaxation remained comparable between groups. In conclusion, vascular functional responses along the descending aorta are altered in metabolic syndrome, exhibiting exaggerated vasocontractility and impaired endothelium-dependent relaxation. These vascular pathologies could potentially underlie the development of cardiovascular disease associated with the metabolic syndrome
Shridhar J Pandya
Gplife Healthcare Pvt Ltd, India
Title: Impact of Gplife Advance Diabetic support tablet in Diabetes
Biography:
Dr. Shridhar J Pandya (Doctor of Philosophy - Pharmaceutical Technology) Managing Director- Gplife Healthcare Pvt Ltd. He got his PhD from JNU & M Pharm from Pune University with Pharmaceutics as a specialization. He has 14 years experience in Pharmaceutical and Nutraceutical research field. He was Professor, Guide of Master’s and PhD scholar students. He published more than 25 national and international papers in reputed journals. He invented more than 50 Nutraceutical and dietary supplement formula of various diseases and many researches are going on. He developed formula with Nutropathy as an alternative option of people with diabetes & for dosage; He designed Pharmaceutical technology to develop Nutraceuticals and Supplements for miraculous output with target delivery system. He is familiar with design expert, SAS software for Optimization. His developed formula approved with Stability, Microbiological & Heavy metal test. He was chair person & Speaker of various international conferences of Diabetes and received best scientist award for his research was published in reputed journals in London, USA, Thailand, China and Singapore. He received young scientist award with best brand invention sponsored by ABP news. He delivered his research at international level in various Pharmaceutical and Nutraceutical conferences. He is author of number of pharmaceutical research, inventor of Patent & international books. His research articles are going to selected as a reference in US Patent also. He is founder and researcher formula of various diseases like Diabetes, Obesity, Cholesterol, Triglycerides, Colon disease, Kidney, Liver disease, Respiratory, Allergy, Blood disorder, Cancer, Skin disease, Autoimmune disorder and B12 problem.
Abstract:
Till date, Diabetic population is going to increase day by day, means something is missing with line of treatment. Diabetes mellitus (DM) is rising in India with more than 62 million diabetic individuals. India (31.7 million) topped world with highest number of people with DM followed by US. Prevalence of DM is predicted to double globally from 171 in 2000 to 366 million in 2030. Gplife Advanced Diabetic Support Tablet was suggestively effective in significantly effective in dropping levels of fasting plasma glucose (FPG) & post meal plasma glucose (PMG). It dropping levels of % HbA1C from baseline to day 60 i.e. end of study. It also significantly effective in increasing levels of C- peptide levels from baseline to day 60 i.e. end of study. C- Peptide is co-secreted with insulin form pancreas and could be used as a tool in diagnosis of DM. When compared to C peptide levels in overall patients there was improvement in c- peptide levels after treatment of Gplife Advanced Diabetic Support Tablet to DM patients. It increases in the HOMA-B score and there was significant decrease in the HOMA-IR score in DM patients. It was concluded that Gplife Advanced Diabetic Support Tablet” used as an adjuvant to OHA and insulin and helps in reducing fasting and post meal blood glucose level along with HbA1c. This can reduce the probable side effects of external insulin and OHA to subjects by providing result oriented and safer alternatives in management of DM
Vinay Singh
Maulana Azad Medical College, India
Title: The Association of FokI Polymorphism with Vitamin D deficiency in Indian Diabetic Population
Biography:
He has done Ph.D. (2014-2019) in Medicine from Faculty of Medical Sciences, University of Delhi, India. His Ph.D. work includes study on Vitamin D levels, VDR gene polymorphism in type 2 diabetes patients. I have also done MBA in Project Management from Sikkim Manipal University, New Delhi and one year full time Advance Post Graduate Diploma in Clinical Research (APGDCR) from Clinical Research Education and Management Academy (CREMA) New Delhi, India. He has one chapter in book Ethics in Clinical Research and 5 publications in indexed journal. Around 10 years of experience in handling different global clinical trials as diabetes, cardiovascular, obesity, dyslipidemia etc., Attended several workshops/conferences and deliver lectures at various podiums
Abstract:
Aim: To determine the association of vitamin D deficiency and the FokI polymorphism of the vitamin D receptor (VDR) gene in Indian diabetic population.
Methodology: The proposed study was conducted in the Department of Medicine and Department of Biochemistry, Maulana Azad Medical College, New Delhi, India and included 162 Type 2 Diabetes Mellitus (T2DM) patients of age 50 years and above who have a history of diabetes for more than five years. Patients who were already taking Vitamin D supplements were excluded from this study. SPSS software was used to analyze the data.
Results: It was found that Vitamin D deficiency (serum 25(OH)D < 20 ng/mL) was more prevalent in wild type (TT) genotype. The association of Vitamin D levels with the FokI polymorphism indicated that there was a progressive increased in Vitamin D levels associated with genotype i.e. patient with wild type (TT) genotype had the lowest level of Vitamin D followed by TC (heterozygous mutant) and CC (mutant). Thus the differential distribution of Vitamin D levels reached a good statistical significance (p=0.0001).
Conclusion: CC (mutant) genotype was found to be associated with maximum Vitamin D levels in Indian diabetic patients. Therefore, maintaining an optimal vitamin D level should be a high priority for diabetic patients in India
Khawla Al Matrooshi
United Arab Emirates Ministry of Health and Prevention, UAE
Title: An Investigation of Physician’s knowledge of The Inter-relationship of Diabetes and Periodontitis
Biography:
Dr. Khawla Ali Majid Almatrooshi. graduated from Ajman University of Science and Technology in 2005 with a Bachelor's Degree. In 2010, I obtained my Master's Degree in executive health care management. By 2017, she specialized in periodontology from Mohamed Bin Rashid University. she currently work at the Ministry of Health and Prevention as a periodontist. During her master study she was intersted in diabetic care in relation to her specialty as so she researched the physican knowledge in regards to diabetic patient and their oral and periodontal health as well as the referral awarness to the periodontist.
Abstract:
Aim:
The purpose of this study is to investigate the knowledge of the physicians’ in regards to diabetes and periodontal health. Studies show a bidirectional relationship between both diabetes and periodontal disease. The UAE lack research that shows us the level of knowledge that physicians have.
Method and material:
Qualitative study in which a questionnaire was distributed to the physicians that attending Arab Health Conference 2016.
Results:
A total of 344 physicians (186 males/ 53.8%, and 159 females/ 46.2%) with average age 38.11±9.31 (Mean±SD) years old responded to the questionnaire given to them. Of those participants, 285 (82.8%) were working in public sectors, and 60 (17.2%) were working in private sectors. One-hundred eight participants (31.4%) graduated in the UAE, and 263 participants (68.6%) graduated from medical schools in other countries. While, 74% see diabetic patients only 19% of them refer to a dentist although 65.5% have good knowledge of the inter relationship of periodontal health and diabetes. Our investigations showed that although the physicians have a good knowledge they rarely refer the patients to receive proper periodontal treatment.
Conclusion:
A proper dental referral protocol should be mandatory for all diabetic patients who attend physicians
Indrashis Mukerjee
Maulana Azad Medical College, India
Title: A Randomised control trial of comparative efficacy of Metformin,, Pioglitazone , Rosuvastatin in metabolic profile of patients with metabolic syndrome
Biography:
Indrashis Mukerjee has completed his M.Sc Biochemistry at the age of 27 years from Himalayan University, Arunachal Pradesh. He has also learnt and standardised many equipments related to Clinical Pharmacology , He has attented many workshops , CME’s and recently I have presented a poster in Diabetes India Conference, Moderated poster in ICOLA Conference in South Korea, Oral in DIACON, Ahemedabad . Presently he is working as JRA in Department of pharmacology & Therepeutics in King George’s Medical University , KGMU, Lucknow, U.P. India. He is also life member of many scientific societies such as Indian Society of Chronomedicine , Indian society of Hypertension , Indian society of Medical Food & nutrition
Abstract:
Metabolic syndrome is a multifactorial heterogenous disorder resulting in a variety of clinical manifestations & considered as a leading global threat. The marked variability in the cholesterol, waist circumference , blood pressure, lipid profile & fasting glucose has been characterised as components of metabolic syndrome.The developing nations are witnessing an increased trend in metabolic syndrome incidence than compared with global incidence. International Diabetes Federation estimated that around 25% of the world’s adult population comes under diagnostic criteria of metabolic syndrome.
Treatment of metabolic syndrome has been under debate & there is no standardized pharmacotherapy yet approved for the same.
The current study was planned to evaluate & compare various potential treatments for the patients of metabolic syndrome. A prospective , open label, parallel group & randomized control trial of 12 weeks study duration was selected in which patients were randomly assigned in 4 groups to receive diet & lifestyle modification, Metformin, Pioglitazone, Rosuvastatin.
Only Rosuvastatin brought about significant increase in serum HDL which is a major marker of cardiovascular risk. Pioglitazone & Rosuvastatin were better than Metformin & lifestyle modification in reduction of serum triglycerides. Results are encouraging & are a step forward in devicing standard pharmacotherapeutic regimes beyond the current treatment modalities.
Ibrahim M. Salman
Alfaisal University, Riyadh, Saudi Arabia
Title: Differential Expression of Vascular Dysfunction of Smaller Diameter Arteries in a Rodent Model of Metabolic Syndrome
Biography:
Dr. Salman received his PhD in Advanced Medicine from Macquarie University (Sydney, Australia) in 2015, and completed his postdoctoral training in the field of neurovascular regulation of cardiorespiratory and renal function at Case Western Reserve University’s School of Medicine (Cleveland, Ohio, United States) in 2017. He is currently an Assistant professor of Physiology and Pharmacology, based in the College of Pharmacy of Alfaisal University (Riyadh, Saudi Arabia). With more than 12 years of research experiences, Dr Salman has contributed more than 50 peer-reviewed publications and has been serving as a reviewer for many leading medical journals in his field.
Abstract:
Metabolic syndrome, driven by obesity and diabetes, is a major contributor to cardiovascular disease. While large arteries vascular dysfunction is a well-documented phenomenon of metabolic syndrome, vascular disease of smaller diameter arteries, which are key contributors to peripheral vascular resistance and blood pressure control, remains uncertain. Using in-vitro organ-bath preparation, this study, therefore, investigated functional responses of the superior mesenteric and right iliac arteries in a high fat diet (HFD)/streptozotocin-induced diabetes mellitus rat model. Five-week-old male Wistar albino rats (n=24) were fed with either HFD (45 kcal% fat) or control diet (10 kcal% fat) for 10 weeks. On week 7, 40mg/kg streptozotocin and saline were injected intraperitoneally into the HFD and control groups, respectively. Diabetic HFD rats displayed a time-dependent increase (p<0.01) in water intake, urine output and fasting blood glucose. Both mesenteric and iliac vasoconstrictor responses (N/g) to norepinephrine (1×10-9–3×10-5M), but not to the depolarizing signals of high K+ (5–120 mM), were greater (p<0.01) in the HFD group relative to controls. Mesenteric, but not iliac, endothelium-dependent vasorelaxation to acetylcholine (1×10-10–1×10-5M) was blunted (p<0.05) in the HFD rats compared with controls. In contrast, mesenteric and iliac endothelium-independent vasorelaxation responses to sodium nitroprusside (1×10-11–1×10-6M) remained comparable between groups. In conclusion, vascular functional responses across smaller diameter arteries are differentially expressed in metabolic syndrome, demonstrating upregulated vasoconstriction to adrenergic stimuli and/or impaired endothelium-dependent relaxation. These vascular abnormalities align with those previously described in larger arteries and could therefore further promote the development of cardiovascular disease in metabolic syndrome
Biography:
Dawit Simegnew Ali is currently a master student at Tsinghua University, China. He has been also among few influential and young researchers in Bule Hora University, Ethiopia, where he worked as a lecturer before joining Tsinghua University. He has publications on reputed journals
Abstract:
Background
Type 2 Diabetes Mellitus (T2DM) patients are increasingly using herbal remedies due to the fact that sticking to the therapeutic regimens is becoming awkward. However, studies towards herbal medicine use by diabetic patients are scarce in Ethiopia. Therefore, the aim of the current study was to explore the prevalence and correlates of herbal medicine use with different sociodemographic variables among type 2 diabetes patients visiting the diabetic follow-up clinic of University of Gondar comprehensive specialized hospital (UOGCSH), Ethiopia.
Methods
A hospital-based cross sectional study was employed on 387 T2DM patients visiting the diabetes illness follow-up care clinic of UOGCSH from October 1 to November 30, 2016. An interviewer-administered questionnaire regarding the demographic and disease characteristics as well as herbal medicine use was completed by the study subjects. Descriptive, univariate and multivariate logistic regression statistics were performed to determine prevalence and come up with correlates of herbal medicine use.
Results
From 387 participants, 62% were reported to be herbal medicine users. The most prevalent herbal preparations used were Garlic (Allium sativum L.) (41.7%), Giesilla (Caylusea abyssinica (fresen.) (39.6%), Tinjute (Otostegia integrifolia Benth) (27.2%), and Kosso (Hagenia abyssinicaa) (26.9%). Most of herbal medicine users (87.1%) didn’t consult their physicians about their herbal medicine use. Families and friends (51.9%) were the frontline sources of information about herbal medicine followed by other DM patients who used herbal medicines (28.9%)