Global Experts Meeting On Diabetes, Hypertension & Metabolic Syndrome

Biography

Biography: Ragaa Abed -El shaheed Matta

Abstract

We found significant relations of serum hepcidin with estradiol, progestron, CT assessed abdominal fat subcutaneous fat (SCF),peritoneal visceral fat(PVF) and liver density, IR indices{fasting blood sugar (FBS), fasting insulin and HOMA-IR} and metabolic syndrome (MetS) among  64postmenpausal (groupI) and 96fertile women (groupII).Among groupII, hormonal assay and hepcidin (ELISA Sandwich method) were assessed during early follicular(groupIIF )and mid luteal phases (groupIIL). GroupI compared to groupIIF and groupIIL, showed significant higher hepcidin (12.8±3.8 versus 6.5±2.6 & 9.5±3.7(ng/ml),p <0.001),iron, ferritin, hepcidin/ferritin ratio(HFR), IR indices. Also theses parameters including hepcidin were significant higher among group IIL than grouIIF . Among these three groups, hepcidin had significant positive correlations with ferritin ,  IR indices ,BMI, waist hip ratio(WHR), blood pressure, lipid profile,SCF, PVF and liver density ,  and significant negative correlation with iron, HDL and eGFR. Interestingly,  hepcidin showed significant positive correlations with estradiol (p<0.001, p=0.013) and progesterone (p<0.001,p=0.003) among groupI&  groupIIF.  . Hepcidin levels increased significantly and linearly with increasing number of MetS features. Among groupIIF and group I, cut off points  of  hepcidin for prediction of MetS  were >5.8 and >10.3 ng/ml with  AUC of  0.91, sensitivity  93.3 % & 100% ; specificity  71.4%&  76.5 % respectively. Stepwise regression analysis for hepcidin as dependent factor: independent factors were: BMI, ferritin, HFR , cholesterol, creatinine among groupI &groupII;  insulin  and HOMA-IR among groupI & groupIIF;  iron ,  LDL , DBP , WHR among groupII,; SCF among groupI; liver density, PVF& Hb among  groupIIL; and SBP, FBS, progesteron , eGFR , TG and  HDL-C among groupIlF.